For the third consecutive season, the Twins will open the baseball season in Missouri.

Just one 250-mile difference.

The Twins and Cardinals will play at Busch Stadium in St. Louis on March 27, 2025, the earliest Opening Day in franchise history. The Twins will also stop in Chicago to meet the White Sox before arriving at Target Field for their April 3 home opener against the Houston Astros.

After opening the 2023 and '24 seasons in Kansas City, the Twins must wait until April 7 to travel to Kaufmann Stadium in 2025, MLB announced Thursday in unveiling all 30 teams' schedules.

The games in St. Louis will mark the second time the Twins have ever opened with an interleague series, having started the 2021 season in Milwaukee. And it's the 12th time in 16 seasons since moving out of the Metrodome that the Twins will open the season on the road, in hopes of avoiding any late-March snowstorms. This time, the Twins will play 10 of their first 13 games on the road.

The Twins, who lost their season opener eight consecutive seasons from 2009 to '16, are 29-34 on Opening Day since moving to Minnesota in 1961.

Baseball's 2025 schedule includes Sacramento for the first time, the new, if temporary, home of the Oakland Athletics. The Twins' first-ever visit to California's capital city comes June 2-5.

Another change: Each team will meet its designated interleague "rival" — the Milwaukee Brewers, in the Twins' case — six times instead of four, three of them coming May 16-18 in Milwaukee, on a new leaguewide "rivalry weekend."

In addition to the Brewers, National League teams scheduled to visit Target Field in 2025 include the New York Mets, Pittsburgh Pirates, Arizona Diamondbacks, San Francisco Giants, San Diego Padres, Chicago Cubs and Washington Nationals — all NL teams the Twins play on the road this season.

The 2025 season will end as it started — on the road in a NL ballpark. The season-ending road trip visits Arlington, Texas, to play the Rangers, and Philadelphia, to meet the Phillies.

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TWINS 2025 SCHEDULE

March 27, 29-30 at St. Louis

March 31-April 2 at Chicago White Sox

April 3, 5-6 Houston

April 7-10 at Kansas City

April 11-13 Detroit

April 14-16 New York Mets

April 18-20 at Atlanta

April 22-24, Chicago White Sox

April 25-27 Los Angeles Angels

April 28-30, May 1 at Cleveland

May 2-4 at Boston

May 6-8 Baltimore

May 9-11 San Francisco

May 13-15 at Baltimore

May 16-18 at Milwaukee

May 19-21 Cleveland

May 23-25 Kansas City

May 26-28 Tampa Bay

May 30-31, June 1 at Seattle

June 2-5 at Athletics (in Sacramento)

June 6-8 Toronto

June 10-12 Texas

June 13-15 at Houston

June 17-19 at Cincinnati

June 20-22 Milwaukee

June 23-26 Seattle

June 27-29 at Detroit

July 1-3 at Miami

July 4-6 at Tampa Bay

July 8-10 Chicago Cubs

July 11-13 Pittsburgh

July 14-17 All-Star Break (July 15 game in Atlanta)

July 18-20 at Colorado

July 21-23 at Los Angeles Dodgers

July 25-27 Washington

July 28-30 Boston

Aug. 1-3 at Cleveland

Aug. 4-6 at Detroit

Aug. 8-10 Kansas City

Aug. 11-13 at New York Yankees

Aug. 14-17 Detroit

Aug. 19-21 Athletics

Aug. 22-24 at Chicago White Sox

Aug. 25-27 at Toronto

Aug. 29-31 San Diego

Sept. 1-4 Chicago White Sox

Sept. 5-7 at Kansas City

Sept. 8-10 at Los Angeles Angels

Sept. 12-14 Arizona

Sept. 15-17 New York Yankees

Sept. 19-21 Cleveland

Sept. 23-25 at Texas

Sept. 26-28 at Philadelphia